Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1002)
DME Name Dipeptidase (pepV), Lactococcus lactis DME Info
UniProt ID
Q84BU9_LACLH
EC Number    EC: 3.4.13.-     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Dipeptidase
EC: 3.4.13.-
Lineage    Species: Lactococcus lactis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Lactococcus
Species: Lactococcus lactis
Subspecies: Lactococcus lactis subsp. hordniae (hT)
Subspecies: Lactococcus lactis subsp. cremoris (L6)
Subspecies: Lactococcus lactis subsp. lactis (L9)
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      43 Xenobiotics
                              American oyster defensin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03111   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation American oyster defensin-1 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [1]
                              Antimicrobial protein AN5-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02298   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial protein AN5-1 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC > 128 ug/ml) [2]
                              Aurein-1.1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02335   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Aurein-1.1 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 25 ug/ml) [3]
                              Bacteriocin lacticin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03771   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin lacticin Q inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [4]
                              Bacteriocin lactocyclicin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03775   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin lactocyclicin Q inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 0.141 microM) [5], [6]
                              Carnocyclin CclA Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02721   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Carnocyclin CclA inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [7], [8]
                              Enterocin 96 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03250   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin 96 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [9]
                              Enterocin L50A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03255   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin L50A inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [10], [11]
                              Enterocin L50B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03256   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin L50B inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [10], [11]
                              Enterocin P Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03257   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin P inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 0.022 ug/ml) [12], [13]
                              Enterocin RJ-11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03258   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin RJ-11 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [14]
                              Enterocin X alpha Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03259   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin X alpha inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 0.813 microM) [15]
                              Fallaxidin 3.1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03381   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fallaxidin 3.1 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 100 microM) [16]
                              Fallaxidin 3.2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03382   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fallaxidin 3.2 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 500 microM) [16]
                              Fallaxidin 4.1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03383   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fallaxidin 4.1 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 12 microM) [16]
                              Garvicin ML Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03473   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Garvicin ML inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [17]
                              Geobacillin I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03478   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Geobacillin I inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [18]
                              Lactococcin Q alpha Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03773   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lactococcin Q alpha inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC > 1 microM) [19]
                              Lactococcin Q beta Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03774   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lactococcin Q beta inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC > 1 microM) [19]
                              Lantibiotic paenibacillin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03806   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lantibiotic paenibacillin inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [20], [21]
                              Leucocyclicin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03857   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Leucocyclicin Q inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 0.038 microM) [6]
                              Nisin U Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04320   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Nisin U inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [22]
                              Plantaricin W alpha Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04622   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin W alpha inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [23]
                              Plantaricin W beta Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04623   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin W beta inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [23]
                              Ponericin G1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04695   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G1 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ponericin G3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04696   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G3 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ponericin G4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04697   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G4 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ponericin G6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04698   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G6 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ponericin-L2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04699   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-L2 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ponericin-W1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04700   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W1 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ponericin-W3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04701   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W3 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ponericin-W4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04702   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W4 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ponericin-W5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04703   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W5 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ponericin-W6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04704   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W6 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [24]
                              Ranatuerin-2AVa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04810   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ranatuerin-2AVa inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [25]
                              Riparin-2.1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04856   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Riparin-2.1 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 25 microM) [26]
                              Sakacin G Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04897   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Sakacin G inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [27], [28]
                              Thuricin-S Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05139   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thuricin-S inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [29]
                              Ubericin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05196   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ubericin-A inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [30]
                              Uperin-3.5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05201   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Uperin-3.5 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 3 ug/ml) [31]
                              Uperin-3.6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05202   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Uperin-3.6 inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis (MIC = 3 ug/ml) [31], [32]
                              Variacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05228   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Variacin inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [33]
                              Weissellin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05283   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Weissellin-A inhibits the drug-metabolizing activity of Dipeptidase (pepV) from Lactococcus lactis [34]
References
1 Purification of a novel arthropod defensin from the American oyster, Crassostrea virginica. Biochem Biophys Res Commun. 2005 Dec 30;338(4):1998-2004.
2 Detection of secreted antimicrobial peptides isolated from cell-free culture supernatant of Paenibacillus alvei AN5. J Ind Microbiol Biotechnol. 2013 Jun;40(6):571-9.
3 The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. Eur J Biochem. 2000 Sep;267(17):5330-41.
4 Structural analysis and characterization of lacticin Q, a novel bacteriocin belonging to a new family of unmodified bacteriocins of gram-positive bacteria. Appl Environ Microbiol. 2007 May;73(9):2871-7.
5 Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus spstrain QU 12. Appl Environ Microbiol. 2009 Mar;75(6):1552-8.
6 Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401. Appl Environ Microbiol. 2011 Nov;77(22):8164-70.
7 Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Appl Environ Microbiol. 2008 Aug;74(15):4756-63.
8 The three-dimensional structure of carnocyclin A reveals that many circular bacteriocins share a common structural motif. J Biol Chem. 2009 Oct 16;284(42):28674-81.
9 Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science. 2003 Mar 28;299(5615):2071-4.
10 Enterocins L50A and L50B, two novel bacteriocins from Enterococcus faecium L50, are related to staphylococcal hemolysins. J Bacteriol. 1998 Apr;180(8):1988-94.
11 Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island. BMC Genomics. 2010 Apr 14;11:239.
12 Biochemical and genetic characterization of enterocin P, a novel sec-dependent bacteriocin from Enterococcus faecium P13 with a broad antimicrobial spectrum. Appl Environ Microbiol. 1997 Nov;63(11):4321-30.
13 Single nucleotide polymorphism analysis of the enterocin P structural gene of Enterococcus faecium strains isolated from nonfermented animal foods. Mol Nutr Food Res. 2006 Dec;50(12):1229-38.
14 Purification and characterization of a novel bacteriocin produced by Enterococcus faecalis strain RJ-11. Appl Environ Microbiol. 2003 Oct;69(10):5746-53.
15 Enterocin X, a novel two-peptide bacteriocin from Enterococcus faecium KU-B5, has an antibacterial spectrum entirely different from those of its component peptides. Appl Environ Microbiol. 2010 Jul;76(13):4542-5.
16 The fallaxidin peptides from the skin secretion of the Eastern Dwarf Tree Frog Litoria fallaxSequence determination by positive and negative ion electrospray mass spectrometry: antimicrobial activity and cDNA cloning of the fallaxidins. Rapid Commun Mass Spectrom. 2008 Oct;22(20):3207-16.
17 Characterization of garvicin ML, a novel circular bacteriocin produced by Lactococcus garvieae DCC43, isolated from mallard ducks (Anas platyrhynchos). Appl Environ Microbiol. 2011 Jan;77(1):369-73.
18 Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5241-6.
19 Lactococcin Q, a novel two-peptide bacteriocin produced by Lactococcus lactis QU 4. Appl Environ Microbiol. 2006 May;72(5):3383-9.
20 Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin. Appl Environ Microbiol. 2007 Jan;73(1):168-78.
21 N-terminal acetylation in paenibacillin, a novel lantibiotic. FEBS Lett. 2008 Aug 6;582(18):2787-92.
22 Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis. Appl Environ Microbiol. 2006 Feb;72(2):1148-56.
23 Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics. Microbiology. 2001 Mar;147(Pt 3):643-651.
24 Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9.
25 Mass spectrometric study of peptides secreted by the skin glands of the brown frog Rana arvalis from the Moscow region. Rapid Commun Mass Spectrom. 2009 May;23(9):1241-8.
26 Host-defence skin peptides of the Australian Streambank Froglet Crinia riparia: isolation and sequence determination by positive and negative ion electrospray mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(5):797-803.
27 Sakacin g, a new type of antilisterial bacteriocin. Appl Environ Microbiol. 2002 Dec;68(12):6416-20.
28 Characterization of a bacteriocin produced by Lactobacillus sakei R1333 isolated from smoked salmon. Anaerobe. 2011 Feb;17(1):23-31.
29 Purification and partial amino acid sequence of thuricin S, a new anti-Listeria bacteriocin from Bacillus thuringiensis. Can J Microbiol. 2007 Feb;53(2):284-90.
30 Ubericin A, a class IIa bacteriocin produced by Streptococcus uberis. Appl Environ Microbiol. 2007 Dec;73(23):7763-6.
31 Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004 Jun;25(6):1035-54.
32 The solution structure of uperin 3.6, an antibiotic peptide from the granular dorsal glands of the Australian toadlet, Uperoleia mjobergii. J Pept Res. 1999 Aug;54(2):137-45.
33 Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis. Appl Environ Microbiol. 1996 May;62(5):1799-802.
34 Purification, amino acid sequence and characterization of the class IIa bacteriocin weissellin A, produced by Weissella paramesenteroides DX. Bioresour Technol. 2011 Jun;102(12):6730-4.

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