Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1063)
DME Name Nitroreductase (NTR), Salmonella enterica DME Info
UniProt ID
A0A5K1UB29_SALTM
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Salmonella enterica     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Salmonella
Species: Salmonella enterica
Subspecies: Salmonella enterica subsp. enterica serovar Typhimurium
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      42 Xenobiotics
                              Antimicrobial peptide HsAp1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02284   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide HsAp1 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 25.0 microM) [1]
                              Antimicrobial peptide HsAp2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02285   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide HsAp2 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 25.0 microM) [1]
                              Antimicrobial peptide HsAp3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02286   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide HsAp3 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 25.0 microM) [1]
                              Antimicrobial peptide HsAp4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02287   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide HsAp4 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 25.0 microM) [1]
                              Arenicin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02317   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Arenicin-1 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 300 microM) [2], [3]
                              Bradykinin-potentiating BmK3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02491   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bradykinin-potentiating BmK3 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 2.3 microM) [4], [5]
                              Cyclic cationic V1 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03029   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V1 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 0.005 microM) [6]
                              Cyclic cationic V2 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03030   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V2 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 0.005 microM) [6]
                              Cyclic cationic V3 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03031   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V3 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 0.3 microM) [6]
                              Cyclic cationic V4 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03032   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V4 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 0.005 microM) [6]
                              Cyclic cationic V5 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03033   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V5 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 0.005 microM) [6]
                              Cyclic cationic V6 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03034   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V6 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 0.528 microM) [6]
                              Cyclic cationic V7 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03035   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cyclic cationic V7 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 0.004 microM) [6]
                              Enterocin 96 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03250   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin 96 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [7]
                              Fish NRC-1 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04335   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fish NRC-1 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 16 ug/ml) [8]
                              Fish NRC-10 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04336   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fish NRC-10 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 16 ug/ml) [8]
                              Fish NRC-16 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04338   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fish NRC-16 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 0.5 ug/ml) [8]
                              Fish NRC-2 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04339   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fish NRC-2 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 64 ug/ml) [8]
                              Fish NRC-3 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04340   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fish NRC-3 peptide inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 2 ug/ml) [8]
                              GAPDH-related antimicrobial YFGAP Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05308   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation GAPDH-related antimicrobial YFGAP inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 0.9 ug/ml) [9]
                              Microcin L Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04114   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Microcin L inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [10], [11]
                              Myxinidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04172   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Myxinidin inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [12]
                              Pleurocidin-like peptide AP1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04642   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide AP1 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 4 ug/ml) [8]
                              Pleurocidin-like peptide AP2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04643   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide AP2 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 2 ug/ml) [8]
                              Pleurocidin-like peptide AP3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04644   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide AP3 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 2 ug/ml) [8]
                              Pleurocidin-like peptide GC3.2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04645   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide GC3.2 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 32 ug/ml) [8]
                              Pleurocidin-like peptide GC3.8 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04646   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide GC3.8 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 1 ug/ml) [8]
                              Pleurocidin-like peptide GcSc4B7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04647   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide GcSc4B7 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 4 ug/ml) [8]
                              Pleurocidin-like peptide GcSc4C5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04648   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide GcSc4C5 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 16 ug/ml) [8]
                              Pleurocidin-like peptide Hb18 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04649   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide Hb18 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC > 64 ug/ml) [8]
                              Pleurocidin-like peptide Hb26 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04650   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide Hb26 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 16 ug/ml) [8]
                              Pleurocidin-like peptide WF3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04651   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide WF3 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 64 ug/ml) [8], [13]
                              Pleurocidin-like peptide WF4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04652   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide WF4 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 4 ug/ml) [8], [13]
                              Pleurocidin-like peptide YT2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04655   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin-like peptide YT2 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica (MIC = 2 ug/ml) [8]
                              Ponericin G1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04695   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G1 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [14]
                              Ponericin G3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04696   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin G3 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [14]
                              Ponericin-L2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04699   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-L2 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [14]
                              Ponericin-W1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04700   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W1 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [14]
                              Ponericin-W3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04701   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W3 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [14]
                              Ponericin-W4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04702   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W4 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [14]
                              Ponericin-W5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04703   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Ponericin-W5 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [14]
                              Tridecaptin A1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05171   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tridecaptin A1 inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [15]
      Natural Product(s), Extract(s) or Medicine(s)
                  Bacterial Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Bacillus licheniformis SP1 culture supernatant Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02990   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Bacillus licheniformis SP1 culture supernatant inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [16]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Anthranilate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02235   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Anthranilate inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [17]
      Pharmaceutical Agent(s)
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Carvacrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01237   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Carvacrol inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [18]
                              L-tryptophan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03968   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation L-tryptophan inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [17]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              (Z)-4-bromo-5-(bromomethylene)-3-ethyl-2(5H)-furanone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01802   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation (Z)-4-bromo-5-(bromomethylene)-3-ethyl-2(5H)-furanone inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [19]
                              2-Hexylmaleic anhydride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01944   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 2-Hexylmaleic anhydride inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [19]
                              3-hexyl-4-bromo-5-methylene-2(5H)-furanone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01990   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 3-hexyl-4-bromo-5-methylene-2(5H)-furanone inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [19]
                              Bromohexylmaleic anhydride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02641   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Bromohexylmaleic anhydride inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Salmonella enterica [19]
References
1 A novel class of antimicrobial peptides from the scorpion Heterometrus spinifer. Peptides. 2012 Dec;38(2):389-94.
2 Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina. FEBS Lett. 2004 Nov 5;577(1-2):209-14.
3 Structure and mode of action of the antimicrobial peptide arenicin. Biochem J. 2008 Feb 15;410(1):113-22.
4 Cloning and characterization of a novel cDNA sequence encoding the precursor of a novel venom peptide (BmKbpp) related to a bradykinin-potentiating peptide from Chinese scorpion Buthus martensii Karsch. IUBMB Life. 2000 Mar;49(3):207-10.
5 Characterization of BmKbpp, a multifunctional peptide from the Chinese scorpion Mesobuthus martensii Karsch: gaining insight into a new mechanism for the functional diversification of scorpion venom peptides. Peptides. 2012 Jan;33(1):44-51.
6 De novo design of potent antimicrobial peptides. Antimicrob Agents Chemother. 2004 Sep;48(9):3349-57.
7 Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science. 2003 Mar 28;299(5615):2071-4.
8 Novel antimicrobial peptides derived from flatfish genes. Antimicrob Agents Chemother. 2003 Aug;47(8):2464-70.
9 Purification and characterization of YFGAP, a GAPDH-related novel antimicrobial peptide, from the skin of yellowfin tuna, Thunnus albacares. Fish Shellfish Immunol. 2012 Oct;33(4):743-52.
10 Genetic analysis and complete primary structure of microcin L. Antimicrob Agents Chemother. 2004 Feb;48(2):505-13.
11 Wild-type Escherichia coli producing microcins B17, D93, J25, and L; cloning of genes for microcin L production and immunity. Can J Microbiol. 2003 May;49(5):357-61.
12 Myxinidin, a novel antimicrobial peptide from the epidermal mucus of hagfish, Myxine glutinosa L. Mar Biotechnol (NY). 2009 Nov-Dec;11(6):748-57.
13 Cloning and developmental expression of a family of pleurocidin-like antimicrobial peptides from winter flounder, Pleuronectes americanus (Walbaum). Dev Comp Immunol. 2001 Mar;25(2):137-47.
14 Ponericins, new antibacterial and insecticidal peptides from the venom of the ant Pachycondyla goeldii. J Biol Chem. 2001 May 25;276(21):17823-9.
15 Biochemical, structural, and genetic characterization of tridecaptin A? an antagonist of Campylobacter jejuni. Chembiochem. 2014 Jan 24;15(2):243-9.
16 Anti-biofilm activity of an exopolysaccharide from a sponge-associated strain of Bacillus licheniformis. Microb Cell Fact. 2011 Sep 27;10:74.
17 Anti-biofilm effects of anthranilate on a broad range of bacteria. Sci Rep. 2017 Aug 17;7(1):8604.
18 The natural antimicrobial carvacrol inhibits quorum sensing in Chromobacterium violaceum and reduces bacterial biofilm formation at sub-lethal concentrations. PLoS One. 2014 Apr 1;9(4):e93414.
19 Structure-activity relationship of brominated 3-alkyl-5-methylene-2(5H)-furanones and alkylmaleic anhydrides as inhibitors of Salmonella biofilm formation and quorum sensing regulated bioluminescence in Vibrio harveyi. Bioorg Med Chem. 2010 Jul 15;18(14):5224-33.

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