Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1731)
DME Name Carbapenemase (cphA), Aeromonas hydrophila DME Info
UniProt ID
BLAB_AERHY
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Aeromonas hydrophila     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Aeromonadales
Family: Aeromonadaceae
Genus: Aeromonas
Species: Aeromonas hydrophila
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      17 Xenobiotics
                              Acaloleptin-A1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02117   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acaloleptin-A1 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [1], [2]
                              Acaloleptin-A2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02118   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acaloleptin-A2 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [1], [2]
                              Acaloleptin-A3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02119   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acaloleptin-A3 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [1], [2]
                              Acaloleptin-A4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02120   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acaloleptin-A4 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [1], [2]
                              Acaloleptin-A5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02121   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acaloleptin-A5 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [1], [2]
                              Antibacterial protein 27kDa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01927   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial protein 27kDa inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila (MIC = 5 ug/ml) [3]
                              Antimicrobial peptide AJN-10 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02277   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide AJN-10 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [4]
                              Arasin-likeSp Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02316   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Arasin-likeSp inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila (MIC > 50 microM) [5]
                              GAPDH-related antimicrobial YFGAP Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05308   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation GAPDH-related antimicrobial YFGAP inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila (MIC = 3.6 ug/ml) [6]
                              Hepcidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03542   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hepcidin inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila (MIC = 6 microM) [7], [8]
                              Histone HIIb-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03567   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Histone HIIb-1 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [9]
                              Histone HIIb-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03568   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Histone HIIb-3 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [9]
                              Histone-derived oncorhyncin III Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04397   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Histone-derived oncorhyncin III inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila (MIC > 0.5 microM) [10]
                              Liver-expressed antimicrobial peptide 2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03915   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Liver-expressed antimicrobial peptide 2 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [11]
                              Oncorhyncin III Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04396   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Oncorhyncin III inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila (MIC > 0.5 microM) [10]
                              Piscidin Pis-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04612   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-1 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila (MIC > 20 microM) [12]
                              Piscidin Pis-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04613   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-2 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila (MIC > 20 microM) [13]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Rosmarinic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01460   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Rosmarinic acid inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [14]
      Natural Product(s), Extract(s) or Medicine(s)
                  Bacterial Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Bacillus sp. QSI-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02363   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Bacillus sp. QSI-1 inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [15]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Peppermint oil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01571   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Peppermint oil inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [16]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Mangifera indica leaf extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03830   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Mangifera indica leaf extract inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [17]
                              Syzygium aromaticum oil Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04386   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Syzygium aromaticum oil inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [18]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Menthol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00416   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Menthol inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [16]
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Curcumin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [19]
                              Epigallocatechin gallate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00613   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Epigallocatechin gallate inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [19]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Vanillin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00727   XEOTIC Info Gene Form Protein
                                 Classification Patented Pharmaceutical Agent
                                 DME Modulation Vanillin inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [20]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              2(5H)-furanone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01914   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 2(5H)-furanone inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Aeromonas hydrophila [21]
References
1 Acaloleptins A: inducible antibacterial peptides from larvae of the beetle, Acalolepta luxuriosa. Arch Insect Biochem Physiol. 1999;40(2):88-98.
2 Multipeptide precursor structure of acaloleptin A isoforms, antibacterial peptides from the Udo longicorn beetle, Acalolepta luxuriosa. Dev Comp Immunol. 2009 Oct;33(10):1120-7.
3 Characterization and ion channel activities of novel antibacterial proteins from the skin mucosa of carp (Cyprinus carpio). Eur J Biochem. 1996 Aug 15;240(1):143-9.
4 Isolation and identification of a novel inducible antibacterial peptide from the skin mucus of Japanese eel, Anguilla japonica. Protein J. 2011 Aug;30(6):413-21.
5 Two novel antimicrobial peptides, arasin-likeSp and GRPSp, from the mud crab Scylla paramamosain, exhibit the activity against some crustacean pathogenic bacteria. Fish Shellfish Immunol. 2011 Feb;30(2):706-12.
6 Purification and characterization of YFGAP, a GAPDH-related novel antimicrobial peptide, from the skin of yellowfin tuna, Thunnus albacares. Fish Shellfish Immunol. 2012 Oct;33(4):743-52.
7 Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide. Peptides. 2009 Apr;30(4):638-46.
8 Isolation and characterization of a hepcidin peptide from the head kidney of large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immunol. 2009 Jun;26(6):864-70.
9 Antimicrobial activity in the skin of the channel catfish Ictalurus punctatus: characterization of broad-spectrum histone-like antimicrobial proteins. Cell Mol Life Sci. 1998 May;54(5):467-75.
10 Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss. Biochem J. 2003 Jul 15;373(Pt 2):621-8.
11 Molecular cloning and expression analysis of the liver-expressed antimicrobial peptide 2 (LEAP-2) gene in grass carp. Vet Immunol Immunopathol. 2010 Feb 15;133(2-4):133-43.
12 Peptide antibiotics in mast cells of fish. Nature. 2001 Nov 15;414(6861):268-9.
13 Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem. 2002 Feb 15;277(7):5030-9.
14 In vitro and in vivo efficacy of rosmarinic acid on quorum sensing mediated biofilm formation and virulence factor production in aeromonas hydrophila.
15 Quorum quenching bacteria Bacillus spQSI-1 protect zebrafish (Danio rerio) from Aeromonas hydrophila infection. Sci Rep. 2014 Jun 25;4:5446.
16 Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram-negative bacteria. Front Microbiol. 2015 May 13;6:420.
17 Leaf extracts of Mangifera indica L. inhibit quorum sensing - regulated production of virulence factors and biofilm in test bacteria. Front Microbiol. 2017 Apr 24;8:727.
18 Influence of clove oil on certain quorum-sensing-regulated functions and biofilm of Pseudomonas aeruginosa and Aeromonas hydrophila. J Biosci. 2013 Dec;38(5):835-44.
19 Combined effects of curcumin and (-)-epigallocatechin gallate on inhibition of N-acylhomoserine lactone-mediated biofilm formation in wastewater bacteria from membrane bioreactor. J Microbiol Biotechnol. 2015 Nov;25(11):1908-19.
20 Anti-biofouling property of vanillin on Aeromonas hydrophila initial biofilm on various membrane surfaces. World J Microbiol Biotechnol. 2013 Sep;29(9):1695-703.
21 2(5H)-Furanone: A Prospective strategy for biofouling-control in membrane biofilm bacteria by quorum sensing inhibition. Braz J Microbiol. 2010 Jan;41(1):227-34.

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