Details of Drug-Metabolizing Enzyme (DME)
General Information of DME (ID: DME1036) | |||||
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DME Name | Cardiac glycoside reductase 2 (cgr2), Eggerthella lenta | ||||
Synonyms | Cardiac glycoside reductase operon protein 2; Cardenolide reductase; Digoxin reductase; cgr2 | ||||
Gene Name | cgr2 | ||||
UniProt ID | |||||
Gene ID | |||||
EC Number | EC: 1.3.2.- (Click to Show/Hide the Complete EC Tree) | ||||
Lineage | Species: Eggerthella lenta (Click to Show/Hide the Complete Species Lineage) | ||||
Interactome(loading-time for this interactome depdends on the speed of web connection) | |||||
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
Tissue Distribution | Primarily distributed in human gut. | ||||
Sequence |
MEYGKCRGIERGMGRRDFLKAATLLGATAAGAGMLAGCAPKSASEAQAQTAPAATGGLDP
ADVDWKYETDVVIVGSGSGGTCAAIEAAEAGADVVVFEKDKAMYGGNSALCGGYMLAAGW STQEEITGYAGDTGEAFANQMLRWSQGLGNQDMIREACLRSGEAVDWMMDTGRTYEGASP LPPVWSCGDTEADVVPRSVYNHNAYGATEGHMATLKKRAESLSNIEIEMGCEVAHILKNA EGSVIGVQLADGSFAKARKGVVMACASVDNNLEMSKDLGLMQNVWGLTLEGAGLLAPGNP DMDSNTGDGVRMLREIGAELCMQQAVCMNDSIYVGGISDWGMSEILGKDVNIHDSSNIDA ILVDKTGRRFCQDDAEWGYVMHECAQAAWKQGFTPDDPTTGYIFYVYDATGAPFFEMKGH TPDTCDTTFSADSVDGLAEFIGCDPTALASEVERWNSFCEAGLDADFGRRANMAPIATPP FYCDVVRPGPMGTFAGAKSNVEAEIIGLDGNPIPRLYGAGCIIGGNVSGAFYFGCGWSIT NTVVWGREAGRNVAALEPWE |
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Function | This enzyme serves as the terminal electron reductase partner to Cardiac glycoside reductase 1 (Cgr1) by forming an complex with Cgr1 and receiving electrons from Cgr1 at the active site FAD redox cofactor. | ||||
Full List of Drug(s) Metabolized by This DME | |||||
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Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Digoxin |
Drug Info | Approved | Cardiac arrhythmia | ICD11: BC65 | [1] |
Full List of Metabolic Reactions (MR) Catalyzed by This DME | ||||||||||||||||||||||||||||
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