Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1090)
DME Name Aminoglycoside phosphotransferase (aph-Ib), Campylobacter jejuni
Synonyms Campylobacter jejuni aminoglycoside phosphotransferase; 2''-aminoglycoside phosphotransferase; Aph(2'')-Ib
Gene Name aph(2'')-Ib
UniProt ID
A0A075C7U3_CAMJU
EC Number    EC: 2.7.1.190     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.190
Lineage    Species: Campylobacter jejuni     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Campylobacteraceae
Genus: Campylobacter
Species: Campylobacter jejuni
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MIDLDVEIYQHLNEQIKINKLCYLSSGDDSDTFLCNEQYVVKVPKRDSVRFAQKREFELY
RFLENCNLSYQTPAVVYQSDRFNIMKYIKGERITYEQYHKLSEKEKDALAYDEATFLKEL
HSIEIDCSVSLFSDALVNKKDKFLQDKKLLISILEKEQLLTDEMLEHIETIYENISSNAV
IFNYIPCLVHNDFSANNLIFRNNRLFGVIDFGDFNVGDPDNDFLCLLDCSTDDFGKEFGR
KVLKYYQHKAPEVAERKAELNDVYWSIDQIIYGYERKDREMLIKGVSELLQTQAEMFIF
Function This enzyme is the most clinically important aminoglycoside-modifying enzyme in Gram-positive bacteria, responsible for high-level resistance in both Enterococci and Staphylococci. And this bacterial enzyme phosphorylates many 4,6-disubstituted aminoglycoside antibiotics that have a hydroxyl group at position 2'', including kanamycin A, kanamycin B, tobramycin, dibekacin, arbekacin, amikacin, gentamicin C, sisomicin and netilmicin.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          4 Drugs
Sisomicin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
Gentamicin
 Drug Info Approved Acute upper respiratory infection ICD11: CA07 [2]
Kanamycin
 Drug Info Approved Pulmonary tuberculosis ICD11: 1B10 [2]
Tobramycin
 Drug Info Approved Conjunctivitis ICD11: 9A60 [2]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Dibekacin
 Drug Info Phase 4 Acute lower respiratory infection ICD11: CA4Z [1]
References
1 Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen. Antimicrob Agents Chemother. 2013 Jan;57(1):452-7.
2 Cloning and expression of novel aminoglycoside phosphotransferase genes from Campylobacter and their role in the resistance to six aminoglycosides. Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01682-17.

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