Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1095)
DME Name Beta-lactamase (blaB), Bacteroides fragilis
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Metallo-beta-lactamase type 2a; Carbapenem and cephamycin resistance; CCRA; Imipenem-cefoxitin hydrolyzing enzyme; Metallo-beta-lactamase type IIa; Zinc-requiring beta-lactamase; ccrA; cfiA
Gene Name ccrA
UniProt ID
BLAB_BACFG
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Bacteroides fragilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKTVFILISMLFPVAVMAQKSVKISDDISITQLSDKVYTYVSLAEIEGWGMVPSNGMIVI
NNHQAALLDTPINDAQTEMLVNWVTDSLHAKVTTFIPNHWHGDCIGGLGYLQRKGVQSYA
NQMTIDLAKEKGLPVPEHGFTDSLTVSLDGMPLQCYYLGGGHATDNIVVWLPTENILFGG
CMLKDNQATSIGNISDADVTAWPKTLDKVKAKFPSARYVVPGHGDYGGTELIEHTKQIVN
QYIESTSKP
Structure
1A7T ; 1A8T ; 1HLK ; 1KR3 ; 1ZNB ; 2BMI ; 2ZNB ; 3ZNB ; 4ZNB
Function This enzyme confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          5 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
Penicillin G
 Drug Info Approved Diphtheria ICD11: 1C17 [2]
Cephalothin
 Drug Info Approved Infectious cystitis ICD11: GC00 [3]
Meropenem
 Drug Info Approved Pseudomonas infection ICD11: 1G40 [1]
Cefazolin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1], [3]
References
1 Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13.
2 Antimicrobial drugs used in the management of anaerobic infections in children. Drugs. 1983 Dec;26(6):520-9.
3 Antibacterial activity of cefoperazone against anaerobic bacteria (author's transl). Jpn J Antibiot. 1980 Nov;33(11):1171-82.

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