Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1321)
DME Name Arylamine N-acetyltransferase (NAT), Tsukamurella paurometabola
Synonyms N-hydroxyarylamine O-acetyltransferase; nhoA; nat; NCTC10741_01829; SAMEA1712962_01653
Gene Name nat
UniProt ID
A0A3P8LE58_TSUPA
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Tsukamurella paurometabola     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Tsukamurellaceae
Genus: Tsukamurella
Species: Tsukamurella paurometabola
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MNDDAAWGAPALDLPRYLHRIGLQAPPAPDLAGLSTLVRAHALTLPWENFDAVRGIPGEL
TIDALQRRMIEGRRGYGCTGHVPLLAAALQRTGFRFGAASGRVLVDGGPSASTHALLIVE
VDGAPHLAEVGFGAVPLAPLRLESGLEQDAGGWRYRLTAEAVGFGEEWRLDFLDPSSGQW
RPQYRFALADRTWSDLRMTNFYVATSPHSPFRGRLMAVVNRPGERHVLTRDAVISTRPDG
FRETVPYVAADRRAILAESFAIDLPEDEAAALAAVSGS
Function This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Isoniazid
 Drug Info Approved Pulmonary tuberculosis ICD11: 1B10 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004151 Aminobenzoic acid N-acetyl-p-aminobenzoic acid Conjugation - N-acetylation Aminobenzoic acid [2]
MR004365 3-aminobenzanthrone 3-AcABA Unclear - Unclear Nitrobenzanthrone [3]
MR004366 3-OH-ABA 3-Aco-ABA Unclear - Unclear Nitrobenzanthrone [3]
References
1 The actinobacterium Tsukamurella paurometabola has a functionally divergent arylamine N-acetyltransferase (NAT) homolog. World J Microbiol Biotechnol. 2019 Oct 31;35(11):174.
2 Human placental transfer and metabolism of p-aminobenzoic acid
3 Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells

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