Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1342)
DME Name Beta-lactamase (blaB), Acinetobacter baumannii
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; blaIMP
Gene Name blaIMP
UniProt ID
A0A1B1FBM9_ACIBA
Gene ID
8458023
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Acinetobacter baumannii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Moraxellaceae
Genus: Acinetobacter
Species: Acinetobacter baumannii
Subspecies: Acinetobacter baumannii ST25
Subspecies: Acinetobacter baumannii ST79
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLISRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          3 Drugs
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [1]
Meropenem
 Drug Info Approved Pseudomonas infection ICD11: 1G40 [2]
Ceftriaxone
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          3 Drugs
Imipenem
 Drug Info Phase 4 Acute pancreatitis ICD11: DC31 [2]
Carbapenem
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [3]
Ceftazidine
 Drug Info Phase 4 Meningitis ICD11: 1A62 [1]
References
1 Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection. Chin Med J (Engl). 2010 Sep;123(18):2571-5.
2 A high mortality rate associated with multidrug-resistant Acinetobacter baumannii ST79 and ST25 carrying OXA-23 in a Brazilian intensive care unit. PLoS One. 2018 Dec 28;13(12):e0209367.
3 Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil. Rev Soc Bras Med Trop. 2019 Dec 20;53:e20190044.

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