Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2655)
Drug Name
Ceftriaxone
Synonyms
Cefatriaxone; Ceftriaxon; Ceftriaxona; Ceftriaxona [INN-Spanish]; Ceftriaxone (INN); Ceftriaxone (TN); Ceftriaxone [USAN:JAN]; Ceftriaxone intravenous; Ceftriaxone, Disodium Salt; Ceftriaxonum; Ceftriaxonum [INN-Latin]; Ceftriazone; Biotrakson; CEFTRIAXONE SODIUM; Longacef; Longaceph; Ro 139904; Ro-13-9904; Ro13-9904; Rocefin; Rocephin; Rocephin (TN); Rocephine; (6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-8-oxo-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-(O-methyloxime), sesquaterhydrate; (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-{[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-3,4-didehydrocepham-4-carboxylic acid; CTRX; Ceftriaxone, Disodium Salt, Hemiheptahydrate; DRG-0071
Indication Methicillin-resistant staphylococcus infection [ICD11: 1D01] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 554.6 Topological Polar Surface Area 288
Heavy Atom Count 36 Rotatable Bond Count 8
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 13
Cross-matching ID
PubChem CID
5479530
PubChem SID
8908 ; 602917 ; 7978887 ; 11693489 ; 14886134 ; 14935103 ; 15968575 ; 39470230 ; 46506458 ; 48415733 ; 50050959 ; 51091963 ; 57363926 ; 79861798 ; 87322639 ; 92711237 ; 103240795 ; 103980019 ; 113985965 ; 124766008 ; 126631063 ; 126657477 ; 134224100 ; 134337467 ; 134338568 ; 135011808 ; 137019029 ; 140116145 ; 141914537 ; 152100037 ; 160964545 ; 162178862 ; 175265409 ; 176267075 ; 179151046 ; 179323748 ; 196109964 ; 210279827 ; 210282150 ; 223653569 ; 223680127 ; 223680436 ; 226412100 ; 241132770 ; 250133954 ; 252122133
ChEBI ID
CHEBI:29007
CAS Number
73384-59-5
TTD Drug ID
D07ACT
Formula
C18H18N8O7S3
Canonical SMILES
CN1C(=NC(=O)C(=O)N1)SCC2=C(N3C(C(C3=O)NC(=O)C(=NOC)C4=CSC(=N4)N)SC2)C(=O)O
InChI
1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1
InChIKey
VAAUVRVFOQPIGI-SPQHTLEESA-N
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Beta-lactamase (blaB) DME1231 Serratia marcescens
AMPC_SERMA
3.5.2.6
[2] , [3]
Beta-lactamase (blaB) DME1024 Klebsiella variicola
BLA2_KLEPO
3.5.2.6
[4]
Beta-lactamase (blaB) DME1342 Acinetobacter baumannii
A0A1B1FBM9_ACIBA
3.5.2.6
[5]
References
1 Ceftriaxone was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 Determination of the antibiotic resistance rates of Serratia marcescens isolates obtained from various clinical specimens. Niger J Clin Pract. 2019 Jan;22(1):125-130.
3 Serratia marcescens is injurious to intestinal epithelial cells. Gut Microbes. 2014;5(6):729-36.
4 Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. J Antimicrob Chemother. 1996 Sep;38(3):409-24.
5 Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection. Chin Med J (Engl). 2010 Sep;123(18):2571-5.

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