Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1415)
DME Name Unclear metabolic mechanism (DME-unclear), Eggerthella lenta
Gene Name DME-unclear
Lineage    Species: Eggerthella lenta     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Eggerthellales
Family: Eggerthellaceae
Genus: Eggerthella
Species: Eggerthella lenta
Subspecies: Eggerthella lenta ATCC 25559
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        21 Drugs
Methylphenidate
 Drug Info Approved Attention deficit hyperactivity disorder ICD11: 6A05 [1]
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Tacrolimus
 Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
Sulfinpyrazone
 Drug Info Approved Uncontrolled gout ICD11: FA25 [1]
Betamethasone valerate
 Drug Info Approved Psoriasis vulgaris ICD11: EA90 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Eszopiclone
 Drug Info Approved Insomnia ICD11: 7A00 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Digoxin
 Drug Info Approved Cardiac arrhythmia ICD11: BC65 [2]
Lovastatin
 Drug Info Approved Hypertriglyceridaemia ICD11: 5C80 [1]
Paclitaxel
 Drug Info Approved Ovarian cancer ICD11: 2C73 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Mefloquine hydrochloride
 Drug Info Approved Malaria ICD11: 1F40 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Norgestimate
 Drug Info Approved Acne vulgaris ICD11: ED80 [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Dicyclomine
 Drug Info Approved Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          4 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Trimebutine
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 Geographic differences in digoxin inactivation, a metabolic activity of the human anaerobic gut flora. Gut. 1989 Jul;30(7):971-7.

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