Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DME1447) | |||||
|---|---|---|---|---|---|
| DME Name | Unclear metabolic mechanism (DME-unclear), Parabacteroides merdae | ||||
| Gene Name | DME-unclear | ||||
| Lineage | Species: Parabacteroides merdae (Click to Show/Hide the Complete Species Lineage) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Tissue Distribution | Primarily distributed in human gut. | ||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 31 Drugs | ||||
Irbesartan |
Drug Info | Approved | Essential hypertension | ICD11: BA00 | [1] |
Mycophenolate mofetil |
Drug Info | Approved | Crohn disease | ICD11: DD70 | [1] |
Tacrolimus |
Drug Info | Approved | Ulcerative colitis | ICD11: DD71 | [1] |
Febuxostat |
Drug Info | Approved | Hyperuricaemia | ICD11: 5C55 | [1] |
Deflazacort |
Drug Info | Approved | Muscular dystrophy | ICD11: 8C70 | [1] |
Digitoxin |
Drug Info | Approved | Congestive heart failure | ICD11: BD10 | [1] |
Levonorgestrel |
Drug Info | Approved | Menorrhagia | ICD11: GA20 | [1] |
Nateglinide |
Drug Info | Approved | Diabetes mellitus | ICD11: 5A10 | [1] |
Norethindrone acetate |
Drug Info | Approved | Menorrhagia | ICD11: GA20 | [1] |
Fluoxetine hydrochloride |
Drug Info | Approved | Depression | ICD11: 6A71 | [1] |
Indomethacin |
Drug Info | Approved | Rheumatoid arthritis | ICD11: FA20 | [1] |
Isradipine |
Drug Info | Approved | Essential hypertension | ICD11: BA00 | [1] |
Budesonide |
Drug Info | Approved | Allergic rhinitis | ICD11: CA08 | [1] |
Danazol |
Drug Info | Approved | Endometriosis | ICD11: GA10 | [1] |
Famciclovir |
Drug Info | Approved | Genital herpes | ICD11: 1A94 | [1] |
Omeprazole |
Drug Info | Approved | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
Sulfasalazine |
Drug Info | Approved | Rheumatoid arthritis | ICD11: FA20 | [1] |
Vilazodone hydrochloride |
Drug Info | Approved | Depression | ICD11: 6A71 | [1] |
Digoxin |
Drug Info | Approved | Cardiac arrhythmia | ICD11: BC65 | [1] |
Losartan potassium |
Drug Info | Approved | Essential hypertension | ICD11: BA00 | [1] |
Lovastatin |
Drug Info | Approved | Hypertriglyceridaemia | ICD11: 5C80 | [1] |
Nizatidine |
Drug Info | Approved | Peptic ulcer | ICD11: DA61 | [1] |
Pantoprazole sodium |
Drug Info | Approved | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
Bromocriptine mesylate |
Drug Info | Approved | Parkinsonism | ICD11: 8A00 | [1] |
Clopidogrel bisulfate |
Drug Info | Approved | Acute coronary syndrome | ICD11: BA4Z | [1] |
Entacapone |
Drug Info | Approved | Parkinsonism | ICD11: 8A00 | [1] |
Megestrol acetate |
Drug Info | Approved | Breast cancer | ICD11: 2C60 | [1] |
Melphalan |
Drug Info | Approved | Multiple myeloma | ICD11: 2A83 | [1] |
Tinidazole |
Drug Info | Approved | Protozoan infection | ICD11: 1F5Z | [1] |
Diflorasone diacetate |
Drug Info | Approved | Rosacea | ICD11: ED90 | [1] |
Ramelteon |
Drug Info | Approved | Insomnia | ICD11: 7A00 | [1] |
| Drugs in Phase 4 Clinical Trial | Click to Show/Hide the Full List of Drugs: 5 Drugs | ||||
Artemisinin |
Drug Info | Phase 4 | Malaria | ICD11: 1F40 | [1] |
Phenazopyridine |
Drug Info | Phase 4 | Infectious cystitis | ICD11: GC00 | [1] |
Bezafibrate |
Drug Info | Phase 4 | Myocardial infarction | ICD11: BA41 | [1] |
Racecadotril |
Drug Info | Phase 4 | Irritable bowel syndrome | ICD11: DD91 | [1] |
Bisacodyl |
Drug Info | Phase 4 | Irritable bowel syndrome | ICD11: DD91 | [1] |
| Drugs in Phase 2 Clinical Trial | Click to Show/Hide the Full List of Drugs: 3 Drugs | ||||
Roxatidine |
Drug Info | Phase 2 | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
W-108598 |
Drug Info | Phase 2 | Myasthenia gravis | ICD11: 8C60 | [1] |
TU-199 |
Drug Info | Phase 2 | Gastro-oesophageal reflux disease | ICD11: DA22 | [1] |
| Drugs in Phase 1 Clinical Trial | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
BRN-0498823 |
Drug Info | Phase 1 | Essential hypertension | ICD11: BA00 | [1] |
| Preclinical/investigative Agents | Click to Show/Hide the Full List of Drugs: 2 Drugs | ||||
ML-236B |
Drug Info | Preclinical | Hypertriglyceridaemia | ICD11: 5C80 | [1] |
Diacetamate |
Drug Info | Investigative | Discovery agent | ICD: N.A. | [1] |
| References | |||||
|---|---|---|---|---|---|
| 1 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | ||||
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