| General Information of DME (ID: DME1552) |
| DME Name |
Cytochrome P450 142A1 (cyp142), Mycobacterium tuberculosis
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| Synonyms |
Cytochrome P450 family 142 subfamily A member 1; Cholest-4-en-3-one C26-monooxygenase 142A1; Cholest-4-en-3-one C26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming] 142A1; Cholesterol C26-monooxygenase 142A1; Cholesterol C26-monooxygenase [(25R)-3beta-hydroxycholest-5-en-26-oate forming] 142A1; MTV023.25c; Rv3518c; Steroid C26-monooxygenase 142A1; Steroid C27-monooxygenase 142A1; cyp142A1
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| Gene Name |
cyp142
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 1.14.15.28 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.28
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| Lineage |
Species: Mycobacterium tuberculosis (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium tuberculosis
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data  |
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MTEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQPELFS
NAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCER
GECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFA
AYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLS
GGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEK
MMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRR
LPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPLG
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| Structure |
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| Pathway |
Microbial metabolism in diverse environments (mtu01120 ) |
| Steroid degradation (mtu00984 ) |
| Function |
This enzyme is a P-450 heme-thiolate protein, and it is involved in degradation of the host cholesterol. The enzyme catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol. The products are exclusively in the (25R) conformation. And it also accepts cholesterol as a substrate.
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