Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1615)
DME Name Naphthalene dioxygenase (doxB), Pseudomonas furukawaii
Synonyms Naphthalene 1,2-dioxygenase ISP alpha; Naphthalene 1,2-dioxygenase subunit alpha; Naphthalene 1,2-dioxygenase system large oxygenase component; ISP NAP; ND subunit alpha; NDO subunit alpha; doxB
Gene Name doxB
UniProt ID
NDOB_PSEU8
EC Number    EC: 1.14.12.12     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.12.12
Lineage    Species: Pseudomonas furukawaii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
Species: Pseudomonas furukawaii
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNYNNKILVSESGLSQKHLIHGDEELFQHELKTIFARNWLFLTHDSLIPAPGDYVTAKMG
IDEVIVSRQNDGSIRAFLNVCRHRGKTLVSVEAGNAKGFVCSYHGWGFGSNGELQSVPFE
KDLYGESLNKKCLGLKEVARVESFHGFIYGCFDQEAPPLMDYLGDAAWYLEPMFKHSGGL
ELVGPPGKVVIKANWKAPAENFVGDAYHVGWTHASSLRSGESIFSSLAGNAALPPEGAGL
QMTSKYGSGMGVLWDGYSGVHSADLVPELMAFGGAKQERLNKEIGDVRARIYRSHLNCTV
FPNNSMLTCSGVFKVWNPIDANTTEVWTYAIVEKDMPEDLKRRLADSVQRTFGPAGFWES
DDNDNMETASQNGKKYQSRDSDLLSNLGFGEDVYGDAVYPGVVGKSAIGETSYRGFYRAY
QAHVSSSNWAEFEHASSTWHTELTKTTDR
Structure
2HMJ ; 2HMK ; 2HML ; 2HMM ; 2HMN ; 2HMO ; 4HJL ; 4HKV ; 4HM0 ; 4HM1 ; 4HM2 ; 4HM3 ; 4HM4 ; 4HM5 ; 4HM6
Function This enzyme is a member of the ring-hydroxylating dioxygenase (RHD) family of bacterial enzymes that play a critical role in the degradation of aromatic compounds, such as polycyclic aromatic hydrocarbons, and it requires Fe2+.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Naproxen
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Isoflavone
 Drug Info Phase 4 Asthma ICD11: CA23 [2]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Flavone
 Drug Info Investigative Colon cancer ICD11: 2B90 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004861 Naproxen Naproxen metabolite M1 Oxidation - Hydrolyzationn Naproxen [1]
References
1 Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway
2 Flavonoids biotransformation by bacterial non-heme dioxygenases, biphenyl and naphthalene dioxygenase. Appl Microbiol Biotechnol. 2011 Jul;91(2):219-28.

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