Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004861)
Formula
SVG example
Hydrolyzationn
Reactant Naproxen Product Naproxen metabolite M1
Reactant Info Product Info
Metabolic Enzyme Naphthalene dioxygenase (doxB) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004875 Naproxen Naproxen O-glucuronide Conjugation - Glucuronidation Naproxen [1]
MR004871 Naproxen O-Desmethylnaproxen Oxidation - O-demethylation Naproxen [2], [3], [1], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008771 Didanosine Hypoxanthine Unclear - Unclear Didanosine [5]
MR005024 Fluoxymesterone Fluoxymesterone Metabolite A7 Reduction - Reduction Fluoxymesterone [6]
MR007507 Inosine Hypoxanthine Unclear Inosine [7], [8]
MR000078 Inosine Hypoxanthine Other reaction - Phosphorylation Adenosine [9], [10]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005025 Fluoxymesterone Metabolite A7 Fluoxymesterone Metabolite A2 Oxidation - Hydrolyzationn Fluoxymesterone [6]
MR005026 Fluoxymesterone Metabolite A7 Fluoxymesterone Metabolite A8 Unclear Fluoxymesterone [6]
MR004862 Naproxen metabolite M1 Naproxen metabolite M2 Unclear Naproxen [11]
References
1 S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen. Br J Clin Pharmacol. 2005 Oct;60(4):423-33.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation. Eur J Clin Pharmacol. 1997;52(4):293-8.
4 [Pharmacokinetics of phenazone after bilateral ovariectomy in female rabbits]
5 Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes
6 Elucidation of urinary metabolites of fluoxymesterone by liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry
7 Metabolism of nicotinamide, adenine and inosine in developing microspore-derived canola (Brassica napus) embryos
8 Inosine in Biology and Disease
9 Adenosine Metabolism: Emerging Concepts for Cancer Therapy Cancer Cell. 2019 Dec 9;36(6):582-596. doi: 10.1016/j.ccell.2019.10.007.
10 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.
11 Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway

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