Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1723)
DME Name Glycosyl hydrolase (glyH), Bacteroides fragilis
Synonyms Glycosidase; Glycoside hydrolase; Furcatin hydrolase; Isoflavonoid 7-O-apiosylglucosidase; BF0853; bglB
Gene Name glyH
UniProt ID
G1091_BACFN
EC Number    EC: 3.2.1.18     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.18
Lineage    Species: Bacteroides fragilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MFKHLNALFIGLALFACTSGAVAQTIKPIETPVPVRPAGQKDVVGLTTPKLDVVRVGFIG
LGMRGPGAVERFTHIPGTQIVALCDLIPERVAGAQKILTKANLPEAASYSGSEDAWKKLC
ERKDIDLVYIATDWKHHAQMAIYAMEHGKHVAIEVPSAMTLDEIWALINTSEKTRKHCMQ
LENCVYDFFELTTLNMAQQGVFGEVLHTEGAYIHNLEDFWPYYWNNWRMDYNQNHRGDVY
ATHGMGPACQLLDIHRGDKMNYLVSMDTKAVNGPAYIKKTTGKEVKDFQNGDQTSTLIRT
EKGKTILIQHNVMTPRPYSRMYQVVGADGYASKYPIEEYCMRPTQIASNDVPNHEKLNAH
GSVPADVKKALMDKYKHPIHKELEETAKKVGGHGGMDYIMDYRLVYCLRNGLPLDMDVYD
LAEWCCMADLTKLSIENSSAPVAIPDFTRGAWNKVKGYRHAFAK
Function This enzyme does not act on 4-O-acetylated sialic acids and it has no alpha-N-acetylgalactosaminidase activity.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
LS-69767
 Drug Info Phase 1 Chronic myelogenous leukaemia ICD11: 2A20 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR001401 Lactulose Lactic acid Oxidation - N-Dealkylation Lactulose [2]
MR001402 Lactulose Formic acid Oxidation - N-Dealkylation Lactulose [2]
MR001403 Lactulose Acetic acid Oxidation - N-Dealkylation Lactulose [2]
References
1 In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.
2 LABEL:ACTULOSE- lactulose solution

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