Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2367)
Drug Name
Lactulose
Synonyms
Lactulosa; Lactulosa [INN-Spanish]; Lactulosa [Spanish]; Lactulosum; Lactulosum [INN-Latin]; Lactulosum [Latin]; Laevolac; Lattulosio [Italian]; Laxilose; Portalac; lactulose; 4-O-beta-D-Galactopyranosyl-D-fructofuranose; 4-O-beta-D-Galactopyranosyl-D-fructose; Acilac; Bifiteral; Cephulac; Cholac; Chronulac; Constilac; Constulose; D-Lactulose; Duphalac; Enulose; Generlac; Heptalac; Isolactose; 4-O-beta-D-galactopyranosyl-beta-D-fructofuranose; 9XH2P2N8EP; BRN 0093773; BRN 6278818; EINECS 225-027-7; UNII-9XH2P2N8EP
Indication Hepatic encephalopathy [ICD11: DB99] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 342.3 Topological Polar Surface Area 190
Heavy Atom Count 23 Rotatable Bond Count 5
Hydrogen Bond Donor Count 8 Hydrogen Bond Acceptor Count 11
Cross-matching ID
PubChem CID
11333
ChEBI ID
CHEBI:6359
CAS Number
4618-18-2
Formula
C12H22O11
Canonical SMILES
C(C1C(C(C(C(O1)OC2C(OC(C2O)(CO)O)CO)O)O)O)O
InChI
1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12-/m1/s1
InChIKey
JCQLYHFGKNRPGE-FCVZTGTOSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Acetic acid DM001682
176
Oxidation - N-Dealkylation 1 [3]
Formic acid DM000198
284
Oxidation - N-Dealkylation 1 [3]
Lactic acid DM000196
612
Oxidation - N-Dealkylation 1 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR001401 Lactulose Lactic acid Oxidation - N-Dealkylation lacZ ... [3]
MR001402 Lactulose Formic acid Oxidation - N-Dealkylation lacZ ... [3]
MR001403 Lactulose Acetic acid Oxidation - N-Dealkylation lacZ ... [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Beta-galactosidase (bgaB) DME2059 Cronobacter sakazakii
BGAL_CROS8
3.2.1.23
[2]
Beta-glucosidase (bglA) DME2060 Enterococcus faecium
Q3Y0M8_ENTFD
3.2.1.21
[2]
Glycosyl hydrolase (glyH) DME2062 Pseudomonas putida
A0A379KQ43_PSEPU
3.2.1.18
[2]
References
1 Lactulose was approved by FDA. The 2020 official website of the U.S. Food and Drug Administration.
2 In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7.
3 LABEL:ACTULOSE- lactulose solution

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