Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001403)
Formula
lacZ ...
SVG example
N-Dealkylation
Reactant Lactulose Product Acetic acid
Reactant Info Product Info
Metabolic Enzyme Beta-galactosidase (bgaB) DME Info
Beta-glucosidase (bglA) DME Info
Glycosyl hydrolase (glyH) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001402 Lactulose Formic acid Oxidation - N-Dealkylation Lactulose [1]
MR001401 Lactulose Lactic acid Oxidation - N-Dealkylation Lactulose [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000046 Acetaldehyde Acetic acid Unclear Acetaldehyde [2], [3], [4]
MR008003 Cefuroxime axetil Acetic acid Unclear - Unclear Cefuroxime axetil [5]
MR007450 Acetaldehyde Acetic acid Oxidation - Oxidationn Ethanol [6]
MR004211 Acetaldehyde Acetic acid Unclear D-xylulose [7]
MR008929 HEDP Acetic acid Unclear - Unclear Fotemustine [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000045 Acetic acid Acetyl-CoA Unclear Acetaldehyde [9], [4], [10]
References
1 LABEL:ACTULOSE- lactulose solution
2 Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism Mol Psychiatry. 2004 Jun;9(6):570-81. doi: 10.1038/sj.mp.4001497.
3 Metabolism of acetaldehyde and custers effect in the yeast Antonie Van Leeuwenhoek. 1981;47(3):209-15. doi: 10.1007/BF00403392.
4 Characterization of Thermotoga neapolitana Alcohol Dehydrogenases in the Ethanol Fermentation Pathway. Biology (Basel). 2022 Sep 5;11(9):1318. doi: 10.3390/biology11091318.
5 DrugBank(Pharmacology-Metabolism):Cefuroxime axetil
6 Ethanol Metabolism in the Liver, the Induction of Oxidant Stress, and the Antioxidant Defense System
7 Effects of increased transaldolase activity on D-xylulose and D-glucose metabolism in Saccharomyces cerevisiae cell extracts
8 Disposition, pharmacokinetics, and metabolism of 14C-fotemustine in cancer patients
9 [The metabolism of alcohol] Rev Med Liege. 2019 May;74(5-6):265-267.
10 ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension. Circulation. 2021 May 25;143(21):2074-2090. doi: 10.1161/CIRCULATIONAHA.120.048845.

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