General Information of DME (ID: DME1957)
DME Name Methylenetetrahydrofolate reductase (metF), Streptococcus sanguinis
Synonyms Methylene tetrahydrofolate reductase bacterial; AtMTHFR; Bacterial MTHFR; SSA_0417; metF
Gene Name metF
UniProt ID
A3CL12_STRSV
Gene ID
4807150
EC Number    EC: 1.5.1.20     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.20
Lineage    Species: Streptococcus sanguinis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus sanguinis
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MVRRHTPSLSFEVFPPNPAVGNDKIFQALREMQDLAPHFISVTASNNKFDIEETTVRLTE
FIANELQIPTIAHLPAVYLTKDMVSNILQSLDRVGVHQILALRGDIFPDVAPKDDFTYAT
DLIEYIKTEAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY
DFQDKCILAGIEVPIHAGIMPILNRNQALRLLKTCENIKLPRKFRAILDKYEHDPESLRA
AGLAYAVDQIVDLVTQDVAGIHLYTMNNAATAYHIYKATHALFNHNPSVQSF
Pathway Carbon metabolism (ssa01200 )
Metabolic pathways (ssa01100 )
Microbial metabolism in diverse environments (ssa01120 )
One carbon pool by folate (ssa00670 )
Function This enzyme is a flavoprotein (FAD). And Menadione can also serve as an electron acceptor.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
ISO-901
Drug Info Phase 1 Rheumatoid arthritis ICD11: FA20 [1]
References
1 Functional profiles of coronal and dentin caries in children. J Oral Microbiol. 2018 Jul 16;10(1):1495976.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.