Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2511)
Drug Name
Glutamic acid
Synonyms
D(-)-Glutamic acid; D-(-)-Glutamic acid; D-2-Aminoglutaric acid; D-2-Aminopentanedioic acid; D-Glutamicacid; D-Glutaminic acid; D-Glutaminsaeure; D-glutamate; D-glutamic acid; Gamma-D-Glutamic Acid; Glutamic acid D-form; Glutamic acid, D-; H-D-Glu-OH; L(+)-Glutamic acid; Lopac-G-2128; Q479989WEA; R-(-)-Glutamic acid; Tocris-0217; WHUUTDBJXJRKMK-GSVOUGTGSA-N; glutamate; (2R)-2-aminopentanedioic acid; (R)-2-aminopentanedioic acid; (r)-glutamic acid; 6893-26-1; CHEBI:15966; CHEMBL76232; D-Glu; DGL; MFCD00063112; UNII-Q479989WEA
Indication Follicular lymphoma [ICD11: 2A80] Phase 3 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 147.13 Topological Polar Surface Area 101
Heavy Atom Count 10 Rotatable Bond Count 4
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Cross-matching ID
PubChem CID
23327
ChEBI ID
CHEBI:15966
CAS Number
6893-26-1
Formula
C5H9NO4
Canonical SMILES
C(CC(=O)O)C(C(=O)O)N
InChI
1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
InChIKey
WHUUTDBJXJRKMK-GSVOUGTGSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Alpha-keto-glutarate DM003195
54539841
Unclear 1 [2]
L-Glutamine DM001343
5961
Unclear 1 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR003637 Glutamic acid Alpha-keto-glutarate Unclear GOT1 [2]
MR003638 Glutamic acid Glutamine Unclear GLUL [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Alanine aminotransferase 1 (GPT) DME0531 Homo sapiens
ALAT1_HUMAN
2.6.1.2
[2]
Aspartate aminotransferase (GOT1) DMEN090 Homo sapiens
AATC_HUMAN
2.6.1.1
[2]
Cytosolic branched aminotransferase (BCAT1) DME0177 Homo sapiens
BCAT1_HUMAN
2.6.1.42
[2]
D-aspartate oxidase (DDO) DME0607 Homo sapiens
OXDD_HUMAN
1.4.3.1
[3]
Glutamate dehydrogenase 1 (GLUD1) DMEN032 Homo sapiens
DHE3_HUMAN
6.3.4.5
[2]
Glutamine synthetase (GLUL) DME0418 Homo sapiens
GLNA_HUMAN
6.3.1.2
[2]
Phosphate-activated glutaminase (PAG) DMEN092 Homo sapiens Not Available Not Available [2]
⏷ Show the Full List of 7  DME(s)
References
1 ClinicalTrials.gov (NCT00369564) Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer
2 Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
3 Secreted d-aspartate oxidase functions in C. elegans reproduction and development. FEBS J. 2019 Jan;286(1):124-138.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.