Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN053)
DME Name Deoxyguanosine kinase (dgk), Bacillus subtilis
Gene Name dgk
UniProt ID
DGK_BACSU
EC Number    EC: 2.5.1.22     (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.22
Lineage    Species: Bacillus subtilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus subtilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLDKFYDNIKEWSFQLEMF
FLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSPHQLEKYKKIYHLLTDDLP
KPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLISDYEVAIKQLQEADPELTVLT
VDGDSKDFVLNKSDFERIAAHVKELIV
Function Plays an essential role in generating the deoxyribonucleotide precursors dGTP for DNA metabolism. Highly specific toward deoxyguanosine (dGuo) and deoxyinosine (dIno). Only marginal activity is observed with guanosine. UTP is slightly more efficient as phosphate donor than CTP, ATP and GTP.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Nelarabine
 Drug Info Approved Acute lymphoblastic leukemia ICD11: 2B33 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR002950 Nelarabine Ara-G Other reaction - Phosphorylation Nelarabine [1], [2]
References
1 A new high-performance liquid chromatography method determines low production of 9-beta-D-arabinofuranosylguanine triphosphate, an active metabolite of nelarabine, in adult T-cell leukemia cells Oncol Rep. 2010 Feb;23(2):499-504.
2 Nelarabine Drugs. 2008;68(4):439-47. doi: 10.2165/00003495-200868040-00004.

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