Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN253)
DME Name Acetyltransferase (AT), Bacteroides fragilis
Gene Name AT
Lineage    Species: Bacteroides fragilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Benzocaine
 Drug Info Approved Anaesthesia ICD11: 9A76-9A78 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Leukotriene C4
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008756 Benzocaine Acetylbenzocaine Conjugation - Acetylation Benzocaine [1]
MR005375 LTE4 (Leukotriene E4) Leukotriene metabolite LTE4NAc Conjugation - Acetylation Leukotriene C4 [2]
References
1 More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems
2 Leukotriene C4 metabolism by hepatoma cells and liver

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