Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN726)
DME Name Ornithine decarboxylase (ODC1), Homo sapiens
Gene Name ODC1
UniProt ID
DCOR_HUMAN
EC Number    EC: 4.1.1.17     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.17
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP
RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI
KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL
LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG
SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ
TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC
DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF
QNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV
Structure
1D7K ; 2ON3 ; 2OO0 ; 4ZGY ; 5BWA ; 7S3F ; 7S3G ; 7U6P ; 7U6U
Function Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
L-Proline
 Drug Info Approved Malnutrition ICD11: 5B50-5B71 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012740 L-Ornithine Putrescine Unclear - Unclear Arginine [2]
MR012741 L-Ornithine L-Glutamyl-y-semialdehyde Unclear - Unclear Arginine [2]
MR008815 Ornithine Putrescine Unclear - Unclear L-Proline [1]
References
1 Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses
2 Arginine Metabolism Revisited

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