Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN825)
DME Name Thymidine kinase (TK1), Homo sapiens
Gene Name TK1
UniProt ID
KITH_HUMAN
EC Number    EC: 2.7.1.21     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.21
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTR
YSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVI
VAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADK
YHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
Structure
1W4R ; 1XBT ; 2ORV ; 2WVJ
Function Cell-cycle-regulated enzyme of importance in nucleotide metabolism . Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate . Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) .
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Valaciclovir
 Drug Info Approved Virus infection ICD11: 1A24-1D9Z [1]
Valacyclovir Hydrochloride
 Drug Info Approved Herpes simplex virus infection ICD11: 1F00 [2]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Clevudine
 Drug Info Phase 3 Hepatitis B virus infection ICD11: 1E50-1E51 [3]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012100 Clevudine L-FMAUDP Unclear - Unclear Clevudine [3]
References
1 DrugBank(Pharmacology-Metabolism):Valaciclovir
2 DrugBank(Pharmacology-Metabolism):Valacyclovir Hydrochloride
3 Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease. Ren Fail. 2014 May;36(4):613-8. doi: 10.3109/0886022X.2014.882240.

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