Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR3533)
Drug Name
Clevudine
Synonyms
Clevudine; 163252-36-6; Levovir; L-FMAU; UNII-IN51MVP5F1; Clevudine (Levovir); IN51MVP5F1; 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)thymine; 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; AK106264; 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione; 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; Clevudine [USAN:INN]; Revovir; Clevudine (USAN)
Indication Hepatitis B virus infection [ICD11: 1E50-1E51] Phase 3 [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 260.22 Topological Polar Surface Area 99.1
Heavy Atom Count 18 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
73115
ChEBI ID
CHEBI:135964
CAS Number
163252-36-6
TTD Drug ID
D0T1WY
Formula
C10H13FN2O5
Canonical SMILES
CC1=CN(C(=O)NC1=O)[C@@H]2[C@@H]([C@H]([C@@H](O2)CO)O)F
InChI
InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1
InChIKey
GBBJCSTXCAQSSJ-XQXXSGGOSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
L-FMAUDP DM019482 N. A. Unclear - Unclear 1 [2]
L-FMAUMP DM015318
503021
Unclear - Unclear 2 [2]
L-FMAUTP DM015319
503024
Unclear - Unclear 2 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR012100 Clevudine L-FMAUDP Unclear - Unclear TK1 ... [2]
MR012101 L-FMAUDP L-FMAUTP Unclear - Unclear PGK2 [2]
MR012102 L-FMAUDP L-FMAUMP Unclear - Unclear DTYMK [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Deoxycytidine kinase (DCK) DME0443 Homo sapiens
DCK_HUMAN
2.7.1.74
[2]
Thymidine kinase (TK1) DMEN825 Homo sapiens
KITH_HUMAN
2.7.1.21
[2]
Thymidine kinase 2 (TK2) DMEN045 Homo sapiens
KITM_HUMAN
Not Available [2]
References
1 2011 Pipeline of Bukwang.
2 Circulating purine compounds, uric acid, and xanthine oxidase/dehydrogenase relationship in essential hypertension and end stage renal disease. Ren Fail. 2014 May;36(4):613-8. doi: 10.3109/0886022X.2014.882240.

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