Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1055)
DME Name Cytidine deaminase (cdd), Escherichia coli
Synonyms Cytidine aminohydrolase; Activation-induced cytidine deaminase; Canine hepatic cyd deaminase; AICDA; JW2131; b2143
Gene Name cdd
UniProt ID
CDD_ECOLI
Gene ID
946663
EC Number    EC: 3.5.4.5     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amidine hydrolase
EC: 3.5.4.5
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Subspecies: Escherichia coli K-12
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDEDALAFALLPLA
AACARTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQTVHAEQSAISHAWLSGEKALA
AITVNYTPCGHCRQFMNELNSGLDLRIHLPGREAHALRDYLPDAFGPKDLEIKTLLMDEQ
DHGYALTGDALSQAAIAAANRSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPL
QGALILLNLKGYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHSIDRVLLA
Structure
1AF2 ; 1ALN ; 1CTT ; 1CTU
Pathway Metabolic pathways (ecj01100 )
Pyrimidine metabolism (ecj00240 )
Function This enzyme catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. It is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Gemcitabine
 Drug Info Approved Breast cancer ICD11: 2C60 [1]
Capecitabine
 Drug Info Approved Colon cancer ICD11: 2B90 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR000752 Decitabine 5-aza-2'-deoxyuridine Oxidation - Deamination Decitabine [3]
MR001122 Gemcitabine 2',2'-Difluorodeoxyuridine Oxidation - Deamination Gemcitabine [4], [5]
References
1 Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep 15;357(6356):1156-1160.
2 LABEL: RIZATRIPTAN BENZOATE
3 Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside Biochem Pharmacol. 1983 Apr 1;32(7):1327-8. doi: 10.1016/0006-2952(83)90293-9.
4 Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective Cancer Chemother Pharmacol. 2016 Jul;78(1):1-12. doi: 10.1007/s00280-016-3003-0.
5 Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer Drugs. 1997 Sep;54(3):447-72. doi: 10.2165/00003495-199754030-00009.

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