Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001122)
Formula
cdd
SVG example
Deamination
Reactant Gemcitabine Product 2',2'-Difluorodeoxyuridine
Reactant Info Product Info
Metabolic Enzyme Cytidine deaminase (cdd) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001121 Gemcitabine Gemcitabine Monophosphate Other reaction - Phosphorylation Gemcitabine [1], [2]
MR012328 Gemcitabine DFdC Unclear - Unclear CO-101 [3]
References
1 Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective Cancer Chemother Pharmacol. 2016 Jul;78(1):1-12. doi: 10.1007/s00280-016-3003-0.
2 Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer Drugs. 1997 Sep;54(3):447-72. doi: 10.2165/00003495-199754030-00009.
3 Phase I study of oral CP-4126, a gemcitabine derivative, in patients with advanced solid tumors

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