Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005334)
Formula
SVG example
Reactant Deoxy-UMP Product 7,8-dihydrofolate (H2folate)
Reactant Info Product Info
Metabolic Enzyme Thymidylate synthase (thyA) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005333 Deoxy-UMP 2'-deoxythymidine-5'-monophosphate (dTMP) Conjugation - Methylationn Deoxy-UMP [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001083 Folic acid Dihydrofolate Reduction - Reduction Folic acid [2]
MR001536 Dihydropteroate Dihydrofolate Unclear L-glutamine [3]
References
1 Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase. Chem Biol. 1995 Sep;2(9):609-14.
2 DrugBank(Pharmacology-Metabolism)Folic acid
3 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.

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