Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM000136)
DM Name
Ezetimibe-glucuronide
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004
Ezetimibe
Conjugation - Glucuronidation Ezetimibe [1] , [2] , [3] , [4]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041
Ezetimibe
Conjugation - Glucuronidation Ezetimibe [1] , [2] , [3] , [4]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME0049
Ezetimibe
Conjugation - Glucuronidation Ezetimibe [1] , [2] , [3] , [4]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040
Ezetimibe
Conjugation - Glucuronidation Ezetimibe [1] , [2] , [3] , [4]
Full List of Drug(s) That Produce This DM By Metabolism
Ezetimibe DR0677 Approved Hypertriglyceridaemia
References
1 Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions. Clin Pharmacokinet. 2005;44(5):467-94.
2 Bioequivalence Study of Ezetimibe Tablets After a Single Oral Dose of 10?mg in Healthy Japanese Subjects Under Fasting Conditions. Clin Pharmacol Drug Dev. 2023 Apr 6. doi: 10.1002/cpdd.1245.
3 Pharmacokinetics and bioequivalence of Ezetimibe tablet versus Ezetrol?:an open-label, randomized, two-sequence crossover study in healthy Chinese subjects. BMC Pharmacol Toxicol. 2023 Feb 3;24(1):7. doi: 10.1186/s40360-023-00649-y.
4 Investigation of the discriminatory ability of analytes for the bioequivalence assessment of ezetimibe: Parent drug, metabolite, total form, and combination of parent drug and total form. Eur J Pharm Sci. 2022 Jul 1;174:106192. doi: 10.1016/j.ejps.2022.106192.

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