General Information of Drug Metabolite (DM) (ID: DM000301)
DM Name
N-desethyl LVM
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 2C8 (CYP2C8) DME0018 Oxidation - Desmethylation Levomilnacipran [1]
Cytochrome P450 2D6 (CYP2D6) DME0009 Oxidation - Desmethylation Levomilnacipran [1]
Cytochrome P450 2J2 (CYP2J2) DME0031 Oxidation - Desmethylation Levomilnacipran [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Desmethylation Levomilnacipran [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Oxidation - Desmethylation Levomilnacipran [1]
Full List of Drug(s) That Produce This DM By Metabolism
Levomilnacipran DR0945 Approved Depression
References
1 The role of levomilnacipran in the management of major depressive disorder: a comprehensive review. Curr Neuropharmacol. 2016;14(2):191-9.

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