| General Information of Drug Metabolite (DM) (ID: DM000406) |
| DM Name |
hydroxyl-suvorexant
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 3A4 (CYP3A4)
|
DME0001
|
| Oxidation - Hydoxylation |
Suvorexant
|
[1] , [2] , [3] |
|
Mephenytoin 4-hydroxylase (CYP2C19)
|
DME0021
|
| Oxidation - Hydoxylation |
Suvorexant
|
[1] , [2] , [3] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| Suvorexant |
DR1521
|
Approved |
Insomnia |
|
|
| References |
| 1 |
Suvorexant: a promising, novel treatment for insomnia. Neuropsychiatr Dis Treat. 2016 Feb 25;12:491-5.
|
| 2 |
CYP450-Mediated metabolism of suvorexant and investigation of metabolites in forensic case specimens Forensic Sci Int. 2020 Jul;312:110307. doi: 10.1016/j.forsciint.2020.110307.
|
| 3 |
In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans Xenobiotica. 2016 Oct;46(10):882-95. doi: 10.3109/00498254.2015.1129565.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
