General Information of Drug Metabolite (DM) (ID: DM000489)
DM Name
27-O-desmethyl temsirolimus
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 2C8 (CYP2C8) DME0018 Oxidation - O-Demethylation Temsirolimus [1]
Cytochrome P450 3A5 (CYP3A5) DME0012 Oxidation - O-Demethylation Temsirolimus [1]
Full List of Drug(s) That Produce This DM By Metabolism
Temsirolimus DR1548 Approved Renal cell carcinoma
References
1 Temsirolimus metabolic pathways revisited Xenobiotica. 2020 Jun;50(6):640-653. doi: 10.1080/00498254.2019.1678793.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.