General Information of Drug Metabolite (DM) (ID: DM000685)
DM Name
S,S-threo-4'-hydroxy-hydrobupropion
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3) DMEN017 Reduction - Ketoreduction Bupropion [1]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME0199 Reduction - Ketoreduction Bupropion [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Oxidation - 4'-Hydroxylation Bupropion [1]
Full List of Drug(s) That Produce This DM By Metabolism
Bupropion DR0247 Approved Nicotine dependence
References
1 DrugBank(Pharmacology-Metabolism)Bupropion

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