Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM000692)
DM Name	S,S-threohydrobupropion

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)	DMEN017	Bupropion	Reduction - Ketoreduction	Bupropion	[1]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DME0199	Bupropion	Reduction - Ketoreduction	Bupropion	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	S,S-threo-4'-hydroxy-hydrobupropion	Oxidation - 4'-Hydroxylation	Bupropion	[1]
UDP-glucuronosyltransferase 2B4 (UGT2B4)	DME0047	S,S-threohydrobupropion glucuronide	Conjugation - Glucuronidation	Bupropion	[1]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DME0040	S,S-threohydrobupropion glucuronide	Conjugation - Glucuronidation	Bupropion	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Bupropion		DR0247	Approved		Nicotine dependence

References
1	DrugBank(Pharmacology-Metabolism)Bupropion

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