Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM001306)
DM Name	Alpha-hydroxy sertraline ketone

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2E1 (CYP2E1)	DME0013	Desmethylsertraline	Oxidation - N-Hydroxylation	Sertraline hydrochloride	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Desmethylsertraline	Oxidation - N-Hydroxylation	Sertraline hydrochloride	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Desmethylsertraline	Oxidation - N-Hydroxylation	Sertraline hydrochloride	[1]
Monoamine oxidase type A (MAO-A)	DME0044	Desmethylsertraline	Oxidation - N-Hydroxylation	Sertraline hydrochloride	[1]
Monoamine oxidase type B (MAO-B)	DME0045	Desmethylsertraline	Oxidation - N-Hydroxylation	Sertraline hydrochloride	[1]

DME(s) Metabolizing This DM

DME Name	DME ID	Product	Reaction	Related Drug	REF
UDP-glucuronyltransferase (UGT)	DMEN064	Sertraline carbamoyl-O-glucuronide	Conjugation - O-Glucuronidation	Sertraline hydrochloride	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Sertraline hydrochloride		DR1477	Approved		Depression

References
1	DrugBank(Pharmacology-Metabolism)Sertraline hydrochloride

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