Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM001445)
DM Name	Bortezomib metabolite M24

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 1A2 (CYP1A2)	DME0003	Bortezomib	Unclear - Unclear	Bortezomib	[1]
Cytochrome P450 2D6 (CYP2D6)	DME0009	Bortezomib	Unclear - Unclear	Bortezomib	[1]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Bortezomib	Unclear - Unclear	Bortezomib	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DME0021	Bortezomib	Unclear - Unclear	Bortezomib	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Bortezomib		DR0221	Approved		Breast cancer

References
1	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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