| General Information of Drug Metabolite (DM) (ID: DM002003) |
| DM Name |
Ertugliflozin metabolite M3
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Conjugation - Glucuronidation |
Ertugliflozin
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[1] , [2] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Conjugation - Glucuronidation |
Ertugliflozin
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[1] , [2] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Ertugliflozin |
DR0604
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Approved |
Diabetes mellitus |
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| References |
| 1 |
In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes Drug Metab Dispos. 2020 Dec;48(12):1350-1363. doi: 10.1124/dmd.120.000171.
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| 2 |
Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects Drug Metab Dispos. 2013 Feb;41(2):445-56. doi: 10.1124/dmd.112.049551.
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