| General Information of Drug Metabolite (DM) (ID: DM002085) |
| DM Name |
Metabolism of the N-propoxymorpholino-group
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| Structure |
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3D MOL is unavailable
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2D MOL is unavailable
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 1A1 (CYP1A1)
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DME0006
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| Unclear - Unclear |
Gefitinib
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Unclear - Unclear |
Gefitinib
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[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Unclear - Unclear |
Gefitinib
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Gefitinib |
DR0764
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Approved |
Lung cancer |
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| References |
| 1 |
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
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