Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM002174)
DM Name	De-benzylated nicardipine

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2C8 (CYP2C8)	DME0018	Nicardipine hydrochloride	Oxidation - N-Dealkylation	Nicardipine hydrochloride	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Nicardipine hydrochloride	Oxidation - N-Dealkylation	Nicardipine hydrochloride	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Nicardipine hydrochloride		DR1144	Approved		Essential hypertension

References
1	Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2	Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.

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