General Information of Drug Metabolite (DM) (ID: DM003224)
DM Name
INCB-024360 Metabolite M12
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A2 (CYP1A2) DME0003 Oxidation - N-dealkylation INCB-024360 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - N-dealkylation INCB-024360 [1]
Mephenytoin 4-hydroxylase (CYP2C19) DME0021 Oxidation - N-dealkylation INCB-024360 [1]
Full List of Drug(s) That Produce This DM By Metabolism
INCB-024360 DR1874 Phase 3 Renal cell carcinoma
References
1 Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans

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