| General Information of Drug Metabolite (DM) (ID: DM005145) |
| DM Name |
Ponesimod M12 Metabolite (ACT-204426)
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 2J2 (CYP2J2)
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DME0031
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| Oxidation - Oxidationn |
Ponesimod
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[1] |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Oxidationn |
Ponesimod
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[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Oxidation - Oxidationn |
Ponesimod
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[1] |
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Cytochrome P450 4F12 (CYP4F12)
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DME0135
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| Oxidation - Oxidationn |
Ponesimod
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[1] |
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Leukotriene B4 omega-hydroxylase (CYP4F3)
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DME0034
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| Oxidation - Oxidationn |
Ponesimod
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Ponesimod |
DR5354
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Approved |
Multiple sclerosis |
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| References |
| 1 |
Mass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans
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