Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM006656)
DM Name
6-Hydroxymethyletoricoxib-1'-N'-oxide
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A2 (CYP1A2) DME0003
Etoricoxib 1'-N'-oxide
Other reaction - 6-methylhydroxylation Etoricoxib [1]
Cytochrome P450 1A2 (CYP1A2) DME0003
6-Hydroxymethyletoricoxib
Oxidation - 1-N-oxidation Etoricoxib [2]
Cytochrome P450 2C9 (CYP2C9) DME0019
Etoricoxib 1'-N'-oxide
Other reaction - 6-methylhydroxylation Etoricoxib [1]
Cytochrome P450 2C9 (CYP2C9) DME0019
6-Hydroxymethyletoricoxib
Oxidation - 1-N-oxidation Etoricoxib [2]
Cytochrome P450 2D6 (CYP2D6) DME0009
Etoricoxib 1'-N'-oxide
Other reaction - 6-methylhydroxylation Etoricoxib [1]
Cytochrome P450 2D6 (CYP2D6) DME0009
6-Hydroxymethyletoricoxib
Oxidation - 1-N-oxidation Etoricoxib [2]
Cytochrome P450 3A4 (CYP3A4) DME0001
Etoricoxib 1'-N'-oxide
Other reaction - 6-methylhydroxylation Etoricoxib [1]
Cytochrome P450 3A4 (CYP3A4) DME0001
6-Hydroxymethyletoricoxib
Oxidation - 1-N-oxidation Etoricoxib [2]
Full List of Drug(s) That Produce This DM By Metabolism
Etoricoxib DR0670 Phase 4 Anaesthesia
References
1 Absorption, metabolism, and excretion of etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, in healthy male volunteers
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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