Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM017111)
DM Name	Carboxyl metabolite enzalutamide (M1)

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Carboxylesterase 1 (CES1)	DME0054	N-desmethyl enzalutamide	Unclear - Unclear	Enzalutamide	[1] , [2]
Carboxylesterase 1 (CES1)	DME0054	Indocyanine green	Multi-steps Reaction - Amide Hydrolysis; Demethylation	Enzalutamide	[1] , [2]
Cytochrome P450 2C8 (CYP2C8)	DME0018	N-desmethyl enzalutamide	Unclear - Unclear	Enzalutamide	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	N-desmethyl enzalutamide	Unclear - Unclear	Enzalutamide	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Enzalutamide		DR0583	Approved		Prostate cancer

References
1	Absorption, Distribution, Metabolism, and Excretion of the Androgen Receptor Inhibitor Enzalutamide in Rats and Dogs
2	Pharmacokinetic Aspects of the Two Novel Oral Drugs Used for Metastatic Castration-Resistant Prostate Cancer: Abiraterone Acetate and Enzalutamide

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