Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM017339)
DM Name	Norbuprenorphine metabolite M1
Structure
Structure	3D MOL is unavailable			2D MOL is unavailable

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DME0004	Norbuprenorphine	Unclear - Unclear	Norbuprenorphine	[1]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DME0041	Norbuprenorphine	Unclear - Unclear	Norbuprenorphine	[1]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DME0040	Norbuprenorphine	Unclear - Unclear	Norbuprenorphine	[1]

Full List of Drug(s) That Produce This DM By Metabolism
Norbuprenorphine		DR3113	Phase 1		Human immunodeficiency virus infection

References
1	Contribution of the different UDP-glucuronosyltransferase (UGT) isoforms to buprenorphine and norbuprenorphine metabolism and relationship with the main UGT polymorphisms in a bank of human liver microsomes. Drug Metab Dispos. 2010 Jan;38(1):40-5.

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