Details of the Drug Metabolite (DM) | INTEDE

General Information of Drug Metabolite (DM) (ID: DM017942)
DM Name	Vonoprazan M-

Full List of Drug-Metabolizing Enzyme (DME) Related to This DM

DME(s) Producing This DM through Metabolism

DME Name	DME ID	Reactant	Reaction	Related Drug	REF
Cytochrome P450 2A6 (CYP2A6)	DME0005	Vonoprazan	Unclear - Unclear	Vonoprazan	[1] , [2]
Cytochrome P450 2B6 (CYP2B6)	DME0020	Vonoprazan	Unclear - Unclear	Vonoprazan	[1] , [2]
Cytochrome P450 3A4 (CYP3A4)	DME0001	Vonoprazan	Unclear - Unclear	Vonoprazan	[1] , [2]

Full List of Drug(s) That Produce This DM By Metabolism
Vonoprazan		DR1705	Phase 4		Gastro-oesophageal reflux disease

References
1	Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date
2	In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.