| General Information of Drug Metabolite (DM) (ID: DM017999) |
| DM Name |
GDC-0623 M13
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 2C9 (CYP2C9)
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DME0019
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| Unclear - Unclear |
GDC-0623
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[1] |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
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| Unclear - Unclear |
GDC-0623
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| GDC-0623 |
DR4047
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Phase 1 |
Solid tumour/cancer |
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| References |
| 1 |
Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor
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