| General Information of Drug Metabolite (DM) (ID: DM019144) |
| DM Name |
Tivantinib Metabolite M12
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Cytochrome P450 3A4 (CYP3A4)
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DME0001
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| Oxidation - Oxidation |
Tivantinib
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[1] |
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Cytochrome P450 3A5 (CYP3A5)
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DME0012
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| Oxidation - Oxidation |
Tivantinib
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Tivantinib |
DR3448
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Phase 3 |
Solid tumour/cancer |
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| References |
| 1 |
Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib
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