| General Information of Drug Metabolite (DM) (ID: DM019143) |
| DM Name |
Tivantinib Metabolite M5
|
|
|
|
|
|
|
|
| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Metabolizing This DM |
| DME Name |
DME ID |
Product |
Reaction |
Related Drug |
REF |
|
Cytochrome P450 3A4 (CYP3A4)
|
DME0001
|
| Oxidation - Oxidation |
Tivantinib
|
[1] |
|
Cytochrome P450 3A5 (CYP3A5)
|
DME0012
|
| Oxidation - Oxidation |
Tivantinib
|
[1] |
|
UDP-glucuronosyltransferase 1A9 (UGT1A9)
|
DME0042
|
| Unclear - Unclear |
Tivantinib
|
[1] |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Full List of Drug(s) That Produce This DM By Metabolism |
| Tivantinib |
DR3448
|
Phase 3 |
Solid tumour/cancer |
|
|
| References |
| 1 |
Stereoselective hydroxylation by CYP2C19 and oxidation by ADH4 in the in vitro metabolism of tivantinib
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
