General Information of Drug Metabolite (DM) (ID: DM019157)
DM Name
MLN4924 Metabolite M3
Structure
3D MOL is unavailable 2D MOL is unavailable
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
Cytochrome P450 1A1 (CYP1A1) DME0006 Oxidation - Hydroxylation MLN4924 [1]
Cytochrome P450 2J2 (CYP2J2) DME0031 Oxidation - Hydroxylation MLN4924 [1]
Cytochrome P450 3A4 (CYP3A4) DME0001 Oxidation - Hydroxylation MLN4924 [1]
Cytochrome P450 3A5 (CYP3A5) DME0012 Oxidation - Hydroxylation MLN4924 [1]
Full List of Drug(s) That Produce This DM By Metabolism
MLN4924 DR3424 Phase 3 Myelodysplastic syndrome
References
1 Metabolism and Disposition of [(14)C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors

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