Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM001007)
DM Name
Hydrazine
Synonyms
HYDRAZINE; Diamine; 302-01-2; Levoxine; Diazane; Oxytreat 35; Hydrazine base; Nitrogen hydride; Hydrazin; Hydrazines; Hydrazyna; Hydrazine, anhydrous; Hydrazyna [Polish]; Hydrazine (anhydrous); RCRA waste number U133; hydrazinyl; H2NNH2; 27RFH0GB4R; N2H4; CHEBI:15571; 119775-10-9; Hydrazine anhydrous; HDZ; CCRIS 335; HSDB 544; EINECS 206-114-9; UN2029; UN3293; Hydrazine/Hydrazine sulfate; RCRA waste no. U133; UNII-27RFH0GB4R; Amerzine; amino nitrogen; Zerox; Catalyzed hydrazine; Scav-Ox II; HYDRAZINE (HYDRAZINE SULFATE); Zerox (Salt/Mix); Amerzine (Salt/Mix); Hydrazine-1,2-diium; HYDRAZINE [MI]; HYDRAZINE [HSDB]; HYDRAZINE [IARC]; NH2NH2; Scav-Ox II (Salt/Mix); HYDRAZINE [WHO-DD]; Hydrazine, anhydrous, 98%; Nitrogen hydride, (N2H4); NH2-NH2; UN 2029 (Salt/Mix); UN 2030 (Salt/Mix); Hydrazine (hydrazine sulphate); Catalyzed hydrazine (Salt/Mix); CHEMBL1237174; DTXSID3020702; H 70 (FUEL); NITROGEN HYDRIDE (N2H4); MFCD00011417; STL281862; AKOS000269060; NCGC00188947-01; BP-13613; ISONIAZID IMPURITY E [EP IMPURITY]; DB-007559; ALLOPURINOL IMPURITY F [EP IMPURITY]; H0172; H0204; H0697; C05361; Q58447; J-017830; Q27110398; HZN
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 32.046 Topological Polar Surface Area 52
Heavy Atom Count 2 Rotatable Bond Count 0
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
PubChem CID
9321
Complexity
0
Formula
H4N2
Canonical SMILES
NN
InChI
InChI=1S/H4N2/c1-2/h1-2H2
InChIKey
OAKJQQAXSVQMHS-UHFFFAOYSA-N
IUPAC name
hydrazine
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
N-acetyltransferase 2 (NAT2) DME0051
Acethydrazide
Oxidation - Deacetylation Isoniazid [1]
DME(s) Metabolizing This DM
DME Name DME ID Product Reaction Related Drug REF
Cytochrome P450 2E1 (CYP2E1) DME0013
Isoniazid reactive metabolite
Unclear - Unclear Isoniazid [1]
N-acetyltransferase 2 (NAT2) DME0051
Acethydrazide
Conjugation - Acetylation Isoniazid [1]
Full List of Drug(s) That Produce This DM By Metabolism
Isoniazid DR0886 Approved Pulmonary tuberculosis
Procarbazine DR1344 Approved Anaplastic large cell lymphoma
References
1 Exploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysis J Pharm Biomed Anal. 2021 Sep 5;203:114223. doi: 10.1016/j.jpba.2021.114223.

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