| General Information of Drug Metabolite (DM) (ID: DM001537) |
| DM Name |
Agomelatine metabolite M5
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| Full List of Drug-Metabolizing Enzyme (DME) Related to This DM |
| DME(s) Producing This DM through Metabolism |
| DME Name |
DME ID |
Reactant |
Reaction |
Related Drug |
REF |
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Mephenytoin 4-hydroxylase (CYP2C19)
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DME0021
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| Oxidation - Demethylation |
Agomelatine
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[1] |
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| Full List of Drug(s) That Produce This DM By Metabolism |
| Agomelatine |
DR0053
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Phase 4 |
Depression |
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| References |
| 1 |
Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches Biochem Pharmacol. 2016 Jun 1;109:70-82. doi: 10.1016/j.bcp.2016.03.020.
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